A chicken liver cell line efficiently supports the replication of ALV-J possibly through its high level viral receptor and efficient protein expression system

A chicken liver cell line efficiently supports the replication of ALV-J possibly through its high level viral receptor and efficient protein expression system

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Abstract In this study, we identified a chicken liver cell line (LMH) which could strongly support the replication of ALV-J (Subgroup J of avian leukosis virus) with high viral titer.Notably, ALV-J was efficiently detected by ELISA in LMH cells 1 day before replica beach walk candle DF1 cells.In comparison with DF1 cells, LMH cells not only expressed higher levels of ALV-J receptor chNHE-1, but also possessed a more efficient protein expression system for foreign genes.Thus, LMH cells could be a novel tool to shorten the ALV-J edgewater shoes eradication approach and accelerate studies on the pathogenesis and oncogenesis of ALV-J.